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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
COPS2
All Species:
43.94
Human Site:
Y421
Identified Species:
60.42
UniProt:
P61201
Number Species:
16
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P61201
NP_001137359.1
443
51597
Y421
Q
K
R
G
G
A
R
Y
T
A
L
D
K
W
T
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001089276
443
51433
Y421
Q
K
R
G
G
A
R
Y
T
A
L
D
K
W
S
Dog
Lupus familis
XP_862009
444
51751
Y422
Q
K
R
G
G
A
R
Y
T
A
L
D
K
W
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8BG32
422
47418
Y397
E
P
P
V
D
K
T
Y
E
A
A
L
E
T
I
Rat
Rattus norvegicus
P61203
443
51578
Y421
Q
K
R
G
G
A
R
Y
T
A
L
D
K
W
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521692
705
77929
V679
D
K
K
G
F
S
A
V
G
A
V
E
D
L
A
Chicken
Gallus gallus
NP_001026767
443
51677
Y421
Q
K
R
G
G
A
R
Y
T
A
L
D
K
W
T
Frog
Xenopus laevis
Q6IR75
441
51318
Y419
Q
K
R
G
G
A
R
Y
T
A
L
D
K
W
T
Zebra Danio
Brachydanio rerio
Q6IQT4
443
51553
Y421
Q
K
R
G
G
A
R
Y
T
A
L
D
K
W
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94899
444
51508
Y422
I
N
S
S
A
S
R
Y
N
A
L
E
K
W
S
Honey Bee
Apis mellifera
XP_392587
444
51537
Y422
K
S
V
C
A
A
R
Y
N
A
L
D
K
W
T
Nematode Worm
Caenorhab. elegans
O01422
495
56762
M472
S
C
H
Q
E
L
S
M
D
G
L
R
V
W
A
Sea Urchin
Strong. purpuratus
XP_780196
444
51783
Y422
K
S
K
D
T
A
R
Y
H
A
L
D
R
W
T
Poplar Tree
Populus trichocarpa
XP_002330981
439
51362
Y417
R
S
K
G
M
K
K
Y
T
A
I
E
K
W
N
Maize
Zea mays
NP_001149870
438
51327
Y417
R
S
K
G
M
R
K
Y
N
A
I
D
K
W
N
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8W207
439
51168
H417
S
G
N
G
R
K
L
H
K
A
V
D
K
W
N
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7SI58
490
56940
F436
S
E
A
V
G
N
L
F
N
A
V
F
K
S
T
Conservation
Percent
Protein Identity:
100
N.A.
98.6
99.3
N.A.
23
100
N.A.
53.9
99.7
98.8
99.3
N.A.
83.7
86.4
57.7
85.5
Protein Similarity:
100
N.A.
98.8
99.3
N.A.
43.1
100
N.A.
57.8
99.7
99.3
100
N.A.
91.4
93.4
72.9
92.1
P-Site Identity:
100
N.A.
93.3
100
N.A.
13.3
100
N.A.
20
100
100
100
N.A.
40
60
13.3
53.3
P-Site Similarity:
100
N.A.
100
100
N.A.
26.6
100
N.A.
46.6
100
100
100
N.A.
60
66.6
13.3
73.3
Percent
Protein Identity:
64.1
64.1
N.A.
60.5
N.A.
45.7
Protein Similarity:
80.1
80.3
N.A.
79
N.A.
65.3
P-Site Identity:
40
40
N.A.
33.3
N.A.
26.6
P-Site Similarity:
73.3
66.6
N.A.
46.6
N.A.
46.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
6
0
12
53
6
0
0
95
6
0
0
0
12
% A
% Cys:
0
6
0
6
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
6
0
0
6
6
0
0
0
6
0
0
65
6
0
0
% D
% Glu:
6
6
0
0
6
0
0
0
6
0
0
18
6
0
0
% E
% Phe:
0
0
0
0
6
0
0
6
0
0
0
6
0
0
0
% F
% Gly:
0
6
0
65
48
0
0
0
6
6
0
0
0
0
0
% G
% His:
0
0
6
0
0
0
0
6
6
0
0
0
0
0
0
% H
% Ile:
6
0
0
0
0
0
0
0
0
0
12
0
0
0
6
% I
% Lys:
12
48
24
0
0
18
12
0
6
0
0
0
77
0
0
% K
% Leu:
0
0
0
0
0
6
12
0
0
0
65
6
0
6
0
% L
% Met:
0
0
0
0
12
0
0
6
0
0
0
0
0
0
0
% M
% Asn:
0
6
6
0
0
6
0
0
24
0
0
0
0
0
18
% N
% Pro:
0
6
6
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
42
0
0
6
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
12
0
42
0
6
6
59
0
0
0
0
6
6
0
0
% R
% Ser:
18
24
6
6
0
12
6
0
0
0
0
0
0
6
12
% S
% Thr:
0
0
0
0
6
0
6
0
48
0
0
0
0
6
53
% T
% Val:
0
0
6
12
0
0
0
6
0
0
18
0
6
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
83
0
% W
% Tyr:
0
0
0
0
0
0
0
77
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _